Feasibility and Acceptability of Personalized Breast Cancer Screening (DECIDO Study): A Single-Arm Proof-of-Concept Trial

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dc.contributor.authorLaza-Vásquez, Celmira
dc.contributor.authorMartínez Alonso, Montserrat
dc.contributor.authorForné Izquierdo, Carles
dc.contributor.authorVilaplana Mayoral, Jordi
dc.contributor.authorCruz Esteve, María Inés
dc.contributor.authorSánchez-López, Isabel
dc.contributor.authorReñé Reñé, Mercè
dc.contributor.authorCazorla, Cristina
dc.contributor.authorHernández Andreu, Marta
dc.contributor.authorGalindo Ortego, Gisela
dc.contributor.authorLlorens Gabandé, Montserrat
dc.contributor.authorPons Rodríguez, Anna
dc.contributor.authorRué i Monné, Montserrat
dc.contributor.authorDECIDO Group
dc.date.accessioned2022-11-16T11:47:17Z
dc.date.available2022-11-16T11:47:17Z
dc.date.issued2022-08
dc.description.abstractThe aim of this study was to assess the acceptability and feasibility of offering risk-based breast cancer screening and its integration into regular clinical practice. A single-arm proof-of-concept trial was conducted with a sample of 387 women aged 40–50 years residing in the city of Lleida (Spain). The study intervention consisted of breast cancer risk estimation, risk communication and screening recommendations, and a follow-up. A polygenic risk score with 83 single nucleotide polymorphisms was used to update the Breast Cancer Surveillance Consortium risk model and estimate the 5-year absolute risk of breast cancer. The women expressed a positive attitude towards varying the frequency of breast screening according to individual risk and, especially, more frequently inviting women at higher-than-average risk. A lower intensity screening for women at lower risk was not as welcome, although half of the participants would accept it. Knowledge of the benefits and harms of breast screening was low, especially with regard to false positives and overdiagnosis. The women expressed a high understanding of individual risk and screening recommendations. The participants’ intention to participate in risk-based screening and satisfaction at 1-year were very high.ca_ES
dc.description.sponsorshipThis research was funded by INSTITUTO DE SALUD CARLOS III, grant number PI17/00834 and co-funded by Fondo Europeo de Desarrollo Regional (FEDER) “Una manera de hacer Europa”, with the support of the Lleida Biomedical Research Institute (IRBLleida) and the CERCA Programme/Generalitat de Catalunya. C.L.V received a grant from the Santander Predoc Program scholarship in 2020 as a predoctoral fellow at the University of Lleida (Agreement 87/2020 of the Consell de Govern, Universitat de Lleida, of 28 April 2020). The non-profit organization Oncolliga Lleida funded part of the genomic analyses for the breast cancer risk assessment. The publication of this article was partly funded by the non-profit women’s breast cancer support association ADIMA Lleida.ca_ES
dc.identifier.doihttps://doi.org/10.3390/ijerph191610426
dc.identifier.idgrec032620
dc.identifier.issn1660-4601
dc.identifier.urihttp://hdl.handle.net/10459.1/84232
dc.language.isoengca_ES
dc.publisherMDPIca_ES
dc.relation.isformatofReproducció del document publicat ahttps://doi.org/10.3390/ijerph191610426ca_ES
dc.relation.ispartofInternational Journal of Environmental Research and Public Health, 2022, vol.19, núm. 16, núm. art. 10426ca_ES
dc.rightscc-by (c) Laza-Vásquez et al., 2022ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBreast cancerca_ES
dc.subjectPersonalized screeningca_ES
dc.subjectPolygenic riskca_ES
dc.subjectRisk assessmentca_ES
dc.subjectAcceptabilityca_ES
dc.subjectFeasibilityca_ES
dc.subjectProof-of-conceptca_ES
dc.titleFeasibility and Acceptability of Personalized Breast Cancer Screening (DECIDO Study): A Single-Arm Proof-of-Concept Trialca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
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