Association of α-klotho with subclinical carotid atherosclerosis in subjects with type 1 diabetes mellitus

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dc.contributor.authorCastelblanco Echavarría, Esmeralda
dc.contributor.authorHernández García, Marta
dc.contributor.authorAlonso, Núria
dc.contributor.authorRibes Betriu, Aina
dc.contributor.authorReal, Jordi
dc.contributor.authorGranado Casas, Minerva
dc.contributor.authorRossell, Joana
dc.contributor.authorRojo López, Marina Idalia
dc.contributor.authorDusso Rosso, Adriana
dc.contributor.authorJulve, Josep
dc.contributor.authorMauricio Puente, Dídac
dc.date.accessioned2022-12-05T10:17:35Z
dc.date.available2022-12-05T10:17:35Z
dc.date.issued2022
dc.description.abstractBackground Compelling evidence suggests that the fbroblast growth factor 23 (FGF23) / α-klotho axis is impaired in subjects with diabetes mellitus. We examined the relationship between parameters related to calcium/phosphate homeostasis, including FGF23 and α-klotho, and subclinical carotid atherosclerosis burden in type 1 diabetes mellitus (T1D) subjects. Methods This cross-sectional study involved 226 subjects with T1D and 147 age-, sex- and plaque matched, nondiabetic (non-T1D) subjects, both with normal renal function. Carotid ultrasound was performed to determine thepresence and burden of atheromatous plaques. Concentrations of the intact form of FGF23 and α-klotho were assessed by ELISA. Calcium, phosphate, parathyroid hormone, and vitamin D levels were also determined. Negative binomial regression models were used to examine relationship between parameters studied and subclinical carotid atherosclerosis. Results Only FGF23 was increased in T1D compared with non-diabetic subjects (> 2-fold; p<0.05). α-klotho was higher in subjects with subclinical carotid atherosclerosis (1.4-fold, p<0.05). Regression analysis revealed that the log α-klotho concentration was positively associated with the presence of subclinical carotid atherosclerosis both in T1D subjects (incidence rate ratio [IRR]: 1.41; 95% confdence interval [CI], 1.06–1.89; p<0.05) and in non-T1D subjects (IRR: 1.65; 95% CI, 1.02–2.75; p<0.05). The models also showed that age, smoking and albuminuria-to-creatinine ratio were positively associated with subclinical carotid atherosclerosis in T1D subjects. Interestingly, sex-related protection against plaque was also revealed in T1D women. Conclusion Higher α-klotho was associated with subclinical carotid atherosclerotic in the absence of kidney dysfunction. This fnding also points to a new pathophysiological pathway involved in the development and progression of this complication.ca_ES
dc.description.sponsorshipThis work was funded by Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III (Madrid, Spain) grant PI15/0625 (to DM and EC), FEDER “Una manera de hacer Europa”, and by CIBER for Diabetes and Associated Metabolic Diseases (CIBERDEM, CB15/00071, PI. Dr. Didac Mauricio) an initiative from ISCIII, Spain, with co-funding from the European Regional Development Fund (ERDF). Miguel Servet Type 2 contract (JJ, CPII18/00004; ISCIII). Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau is accredited by the Generalitat de Catalunya as Centre de Recerca de Catalunya (CERCA).ca_ES
dc.identifier.doihttps://doi.org/10.1186/s12933-022-01640-3
dc.identifier.issn1475-2840
dc.identifier.urihttp://hdl.handle.net/10459.1/84473
dc.language.isoengca_ES
dc.publisherBMCca_ES
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1186/s12933-022-01640-3ca_ES
dc.relation.ispartofCardiovascular Diabetology, 2022, vol. 21, núm. 1ca_ES
dc.rightscc-by (c) authors, 2022ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectType 1 diabetes mellitusca_ES
dc.subjectMineral metabolismca_ES
dc.subjectFibroblast growth factor 23ca_ES
dc.subjectα-klothoca_ES
dc.titleAssociation of α-klotho with subclinical carotid atherosclerosis in subjects with type 1 diabetes mellitusca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
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