L'IRBLleida és un centre de recerca conjunt entre la Universitat i el Departament de Salut de la Generalitat de Catalunya. Té com a funció potenciar les sinergies de recerca biomèdica entre ambdós institucions i està compromès en avançar en la recerca biomèdica com a mitja per millorar la salut de la població i facilitar una activitat assistencial òptima en situacions de malaltia. [Més informació].

Recent Submissions

  • Factors influencing intention to participate in breast cancer screening. An exploratory structural model 

    López-Panisello, María Belén; Pérez Lacasta, María José; Rué i Monné, Montserrat; Carles Lavila, Misericordia (Public Library of Science, 2023-02-03)
    Objectives The paper has two objectives. The first one examines whether informing women about the benefits and adverse effects of breast cancer screening could have an effect on three variables: their knowledge, the ...
  • Comparative evaluation of acetaminophen form (I) in commercialized paracetamol brands 

    Oyebayo Oloyede, Oyedibu; Oluwatayo Alabi, Zacchaeus; Olalekan Akinyemi, Amos; Faith Oyelere, Sunday; Banky Oluseye, Amuwaolorun; Dayo Owoyemi, Bolaji Charles (Elsevier B.V. on behalf of African Institute of Mathematical Sciences, 2023)
    The vibrational spectroscopy (FT-IR/Raman) and X-ray diffraction techniques are combined alongside the principal component analysis (PCA) as novel integrated analytical techniques to comparatively investigate latent chemical ...
  • Survival motor neuron protein and neurite degeneration are regulated by Gemin3 in spinal muscular atrophy motoneurons 

    Miralles, Maria P.; Sansa Zaragoza, Alba; Beltran Perelló, Maria; Soler i Tatché, Rosa Ma.; Garcera, Ana (Frontiers Media, 2022)
    Spinal Muscular Atrophy (SMA) is a genetic neuromuscular disorder caused by reduction of the ubiquitously expressed protein Survival Motor Neuron (SMN). Low levels of SMN impact on spinal cord motoneurons (MNs) causing ...
  • Epidemiological Characteristics and Spatio-Temporal Distribution of Hepatitis A in Spain in the Context of the 2016/2017 European Outbreak 

    Guerrero-Vadillo, María; Peñuelas, Marina; Domínguez, Ángela; Godoy i García, Pere; Gómez-Barroso, Diana; Soldevila, Núria; Izquierdo, Conchita; Martínez, Ana; Torner, Núria; Avellón, Ana; Rius, Cristina; Varela, Carmen (MDPI, 2022)
    The aim of our study was to describe the results of the epidemiological surveillance of hepatitis A infections in Spain in the context of the 2016/2017 European outbreak, particularly of hepatitis A outbreaks reported ...
  • Relevance of Molecular Profiling in Patients with Low-Grade Endometrial Cancer 

    Vrede, Stephanie W.; Kasius, Jenneke; Bulten, Johan; Teerenstra, Steven; Huvila, Jutta; Colás, Eva; Gil-Moreno, Antonio; Boll, Dorry; Vos, Maria Caroline; Van Altena, Anne M.; Asberger, Jasmin; Sweegers, Sanned; Van Weelden, Willem Jan; Van Der Putten, Louis J.M.; Amant, Frédéric; Visser, Nicole C.M.; Snijders, Marc P.L.M.; Küsters-Vandevelde, Heidi V.N.; Kruitwagen, Roy; Matias-Guiu, Xavier; Weinberger, Vit; Reijnen, Casper; Pijnenborg, Johanna M.A. (American Medical Association, 2022)
    IMPORTANCE Patients with low-grade (ie, grade 1-2) endometrial cancer (EC) are characterized by their favorable prognosis compared with patients with high-grade (ie, grade 3) EC. With the implementation of molecular ...
  • Impact of a Primary Care Antimicrobial Stewardship Program on Bacterial Resistance Control and Ecological Imprint in Urinary Tract Infections 

    Jover, Alfredo; Ramírez-Hidalgo, María; Bellés Bellés, Alba; Ribes Murillo, Esther; Batlle Bosch, Meritxell; Cayado Cabanillas, José; Garrido-Calvo, Sònia; Gracia Vilas, María Isabel; Gros Navés, Laura; Javierre Caudevilla, María Jesús; Mari López, Alba; Montull Navarro, Lidia; Ortiz Valls, Mireia; Terrer Manrique, Gemma; Vaqué Castilla, Pilar; Ichart Tomás, José Javier; Justribó Sánchez, Elena; Andreu Mayor, Ester; Carrera Guiu, Joan; Martorell Solé, Roser; Pallàs Satué, Silvia; Saura Codina, Mireia; Vena Martínez, Ana; Albalat Samper, José Manuel; Cano Marrón, Susana; Chacón Domínguez, Isabel; de la Rica Escuin, David; Estadella Servalls, María José; Figueres Farreny, Ana M.; Minguet Vidal, Sonia; Montaña Esteban, Luís Miguel; Otal Bareche, Josep; Pallerola Planes, Mercè; Pujol Aymerich, Francesc; Rodríguez Garrocho, Andrés; Solé Curcó, Antoni; Toribio Redondo, Francisca; Urgelés Castillón, María Cruz; Valgañon Palacios, Juan; Torres Puig-gros, Joan (MDPI, 2022)
    Antimicrobial stewardship programs (ASPs) are a central component in reducing the overprescription of unnecessary antibiotics, with multiple studies showing benefits in the reduction of bacterial resistance. Less commonly, ...
  • Proteomic profiling for prediction of recurrent cardiovascular event in patients with acute coronary syndrome and obstructive sleep apnea: A post-hoc analysis from the ISAACC study 

    Zapater, Andrea; Gracia-Lavedan, Esther; Torres, Gerard; Minguez Roure, Olga; Pascual, Lydia; Cortijo, Anunciación; Martínez, Dolores; Benítez, Iván; Batlle Garcia, Jordi de; Henríquez Beltrán, Mario; Abad, Jorge; Durán-Cantolla, Joaquín; Urrutia, Amaia; Mediano, Olga; Masdeu, María José; Ordax-Carbajo, Estrella; Masa, Juan Fernando; Peña, Mónica de la; Mayós Pérez, Mercè; Coloma, Ramón; Montserrat, Josep Maria; Chiner, Eusebi; Barbé Illa, Ferran; Sánchez de la Torre, Manuel (Elsevier, 2023)
    Background: Obstructive sleep apnea (OSA) is associated with a recurrent cardiovascular event (CVE) risk in patients with a first acute coronary syndrome (ACS). However, the pathological pathways by which OSA promotes this ...
  • DPP9 as a Potential Novel Mediator in Gastrointestinal Virus Infection 

    Castillo Izquierdo, Ángela del; Moreno Navarrete, José María; Latorre, Jèssica; Arnoriaga Rodríguez, María; Ballanti, Marta; Monteleone, Giovanni; Paoluzi, Alessandro Omero; Mingrone, Geltrude; Puig, Josep; Ramos, Rafael; Garre Olmo, Josep; Jové Font, Mariona; Pamplona Gras, Reinald; Portero Otín, Manuel; Sol, Joaquim; Lefevre, Philippe; Staels, Bart; Federici, Massimo; Fernández Real, José Manuel; Mayneris Perxachs, Jordi (MDPI, 2022)
    Dipeptidyl peptidase 9 (DPP9) is a member of the dipeptidyl peptidase IV family. Inhibition of DPP9 has recently been shown to activate the nucleotide-binding domain leucine-rich repeat 1 (NLRP1) inflammasome. NLRP1 is ...
  • Traumatic Brain Injury and Acute Kidney Injury—Outcomes and Associated Risk Factors 

    Barea-Mendoza, Jesús Abelardo; Chico-Fernández, Mario; Quintana-Díaz, Manuel; Servià Goixart, Lluís; Fernández-Cuervo, Ana; Bringas-Bollada, María; Ballesteros Sanz, María Ángeles; García-Sáez, Íker; Pérez-Bárcena, Jon; Llompart-Pou, Juan Antonio (MDPI, 2022)
    Our objective was to analyze the contribution of acute kidney injury (AKI) to the mortality of isolated TBI patients and its associated risk factors. Observational, prospective and multicenter registry (RETRAUCI) methods ...
  • Are Transcription Factors Plausible Oncotargets for Triple Negative Breast Cancers? 

    Marqués, Marta; Urdanibia, Izaskun; Parisi Capdevila, Eva; Hidalgo, Iván; Morales Murillo, Serafín; Salud Salvia, Maria Antonieta; Sorolla Bardají, Anabel; Sorolla Bardají, Maria Alba (MDPI, 2022)
    Breast cancer (BC) is the most diagnosed cancer worldwide and one of the main causes of cancer deaths. BC is a heterogeneous disease composed of different BC intrinsic subtypes such as triple-negative BC (TNBC), which ...
  • Dark Triad Traits, Social Position, and Personality: A Cross-Cultural Study 

    Aluja Fabregat, Antón; García, Luis Francisco; Rossier, Jérôme; Ostendorf, Fritz; Glicksohn, Joseph; Oumar, Barry; Bellaj, Tarek; Ruch, Willibald; Wang, Wei; Suranyi, Zsuzsanna; Ścigała, Dawid; Čekrlija, Đorđe; Stivers, Adam; Di Blas, Lisa; Valdivia, Mauricio; Ben Jemaa, Sonia; Atitsogbe, Kokou A.; Hansenne, Michel (SAGE Publications, 2022)
    This research explores the Dark Triad traits in 18 cultures from Europe, America, Africa, and Asia. We examined the relationships among Dark Triad traits, as measured by the SD3, with gender, age, social status, and two ...
  • Who’s in the House? Staffing in Long-Term Care Homes Before and During COVID-19 Pandemic 

    Vellani, Shirin; Spilsbury, Karen; Zúñiga, Franziska; Backman, Annica; Kusmaul, Nancy; Scales, Kezia; Chu, Charlene H.; Mateos, José Tomás; Wang, Jing; Fagertun, Anette; McGilton, Katherine S. (SAGE Publications, 2022)
    Critical gaps exist in our knowledge on how best to provide quality person-centered care to long-term care (LTC) home residents which is closely tied to not knowing what the ideal staff is complement in the home. A ...
  • A detailed review on the phytochemical profiles and anti-diabetic mechanisms of Momordica charantia 

    Faith Oyelere, Sunday; Hezekiah Ajayi, Oluwatobi; Eunice Ayoade, Titilayo; Santana Pereira, George; Dayo Owoyemi, Bolaji Charles; Olaoluwa Ilesanmi, Ajibola; Amos Akinyemi, Olalekan (Elsevier, 2022)
    Diabetes mellitus is the most well-known endocrine dilemma suffered by hundreds of million people globally, with an annual mortality of more than one million people. This high mortality rate highlights the need for in-depth ...
  • Beyond the Glycaemic Control of Dapagliflozin: Microangiopathy and Non-classical Complications 

    Bellido, Virginia; Martínez, Julia; Calvo, Fernando; Villarroel, Aida; Lecumberri, Edurne; Moreno, Juan; Morillas, Carlos; Rodrigo, Silvia; Izarra, Aitziber; Lecube Torelló, Albert (Springer Nature, 2022)
    Dapagliflozin is a selective sodium-glucose cotransporter 2 inhibitor (SGLT2i) indicated for the treatment of type 2 diabetes mellitus (T2DM), heart failure (HF) with reduced ejection fraction (EF) and chronic kidney disease ...
  • Increase of burnout among emergency department professionals due to emotional exhaustion during the SARS-Cov2 pandemic: Evolution from 2016 to 2021 

    Yuguero Torres, Oriol; Rius, Nuria; Soler González, Jorge; Esquerda i Aresté, Montse (Wolters Kluwer Health, 2022)
    The objective is to establish there have been any significant changes in the evolution of levels of burnout and empathy at the different Emergency Department in our region, bearing the severe acute respiratory syndrome ...
  • Adjusting RFR by Predictors of Disagreement, “The Adjusted RFR”: An Alternative Methodology to Improve the Diagnostic Capacity of Coronary Indices 

    Fernández Rodríguez, Diego; Casanova Sandoval, Juan Manuel; Barriuso, Ignacio; Rivera, Kristian; Otaegui, Imanol; García del Blanco, Bruno; Gil Jiménez, Teresa; López Pérez, Manuel; Rodríguez Esteban, Marcos; Torres Saura, Francisco; Jiménez Díaz, Víctor; Ocaranza Sánchez, Raymundo; Peral Disdier, Vicente; Sánchez Elvira, Guillermo; Worner, Fernando (Sociedade Brasileira de Cardiologia, 2022)
    Background: Cutoff thresholds for the "resting full-cycle ratio" (RFR) oscillate in different series, suggesting that population characteristics may influence them. Likewise, predictors of discordance between the RFR and ...
  • Litotricia intracoronaria como rescate de un stent infraexpandido 

    Rivera, Kristian; Fernández Rodríguez, Diego; Zielonka, Marta; Barriuso, Ignacio; Pueyo, Núria; Casanova Sandoval, Juan Manuel (Permanyer, 2022)
  • Elimination of Vitamin D Signaling Causes Increased Mortality in a Model of Overactivation of the Insulin Receptor: Role of Lipid Metabolism 

    Crespo Masip, Maria; Pérez-Gómez, Aurora; Garcia Carrasco, Alicia; Jover, Ramiro; Guzmán, Carla; Dolcet Roca, Xavier; Ibarz Escuer, Mercedes; Martínez, Cristina; Eritja, Àuria; Díaz Tocados, Juan Miguel; Valdivielso Revilla, José Manuel (MDPI, 2022)
    Vitamin D (VD) deficiency has been associated with cancer and diabetes. Insulin signaling through the insulin receptor (IR) stimulates cellular responses by activating the PI3K/AKT pathway. PTEN is a tumor suppressor and ...
  • Cardiac tamponade as the initial presentation of a T-cell lymphoblastic lymphoma 

    Belokopytova-Chakh, Alena; Ruiz González, Agustín; Vilardell, Felip; Porcel Pérez, José Manuel (Sociedad Gallega de Medicina Interna, 2022)
    We report a 27-year-old man who presented with cardiac tamponade and was eventually diagnosed of T-cell lymphoblastic lymphoma (T-LBL) by the flow cytometric analysis of pericardial fluid. Despite pericardiocentesis and ...
  • Industrial By-Products As a Novel Circular Source of Biocompatible Extracellular Vesicles 

    Lorca, Cristina; Laparra, Moisés; Céspedes, María Virtudes; Casaní, Laura; Florit, Sergi; Jové Font, Mariona; Mota Martorell, Natàlia; Vilella, Elisabet; Gallart-Palau, Xavier; Serra, Aida (Wiley, 2022)
    Extracellular vesicles (EVs) constitute an intricate system of molecular exchange that has recently gained tremendous interest. However, sustainable sources of safe biological EVs remain scarce and elusive. This study ...

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