Articles publicats (Grup de Recerca en Neurobiologia Cel·lular)
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Neuregulin 1-ErbB module in C-bouton synapses on somatic motor neurons: molecular compartmentation and response to peripheral nerve injury
(Nature, 2017)The electric activity of lower motor neurons (MNs) appears to play a role in determining cell-vulnerability in MN diseases. MN excitability is modulated by cholinergic inputs through C-type synaptic boutons, which display ... -
An early and robust activation of caspases heads cells for a regulated form of necrotic-like cell death
(American Society for Biochemistry and Molecular Biology, 2015)Apoptosis is triggered by the activation of caspases and characterized by chromatin condensation and nuclear fragmentation (type II nuclear morphology). Necrosis is depicted by a gain in cell volume (oncosis), swelling ... -
Adverse effects of a SOD1-peptide immunotherapy on SOD1(G93A) mouse slow model of amyotrophic lateral sclerosi
(Elsevier, 2015-12-01)Previous reports from our lab had shown that some anti-purinergic receptor P2X4 antibodies cross-reacted with misfolded forms of mutant Cu/Zn superoxide dismutase 1 (SOD1), linked to amyotrophic lateral sclerosis (ALS). ... -
Caspase-independent type III programmed cell death in chronic lymphocytic leukemia: the key role of the F-actin cytoskeleton
(Ferrata Storti Foundation, 2009)Background Programmed cell death has been traditionally related with caspase activation. However, it is now accepted that caspase-independent forms of programmed cell death also regulate cell death. In chronic lymphocytic ... -
Autophagy exacerbates caspase-dependent apoptotic cell death after short times of starvation
(Elsevier, 2015-12)Autophagy is generally regarded as a mechanism to promote cell survival. However, autophagy can occasionally be the mechanism responsible of cell demise. We have found that a concomitant depletion of glucose, nutrients and ... -
7-Bromoindirubin-3'-oxime uncovers a serine protease-mediated paradigm of necrotic cell death
(Elsevier, 2008)The new 7-bromoindirubin-3′-oxime (7BIO) compound induces caspase-independent cell death in all cell lines tested to date. Irrespective of the cell line, a 25 μM treatment for 24 h is lethal for the entire cell population. ... -
BAX and BAK proteins are required for cyclin-dependent kinase inhibitory drugs to cause apoptosis
(American Association for Cancer Research, 2008)In previous reports we have shown in SH-SY5 cells that Olomoucine and Roscovitine, two inhibitory drugs of Cyclin Dependent Kinases, caused apoptosis independent of the extrinsic pathway. In this experimental paradigm, ... -
Trancriptional modulation of apoptotis regulators by Roscovitine and related compounds
(Springer Science Business Media, 2011)Chemical inhibitors of cyclin-dependent kinase (CDK), like roscovitine, are promising drugs in thecontext of new cancer therapies. Roscovitine and related compounds, like seliciclib and olomoucine, are effective inducers ... -
Pharmacological Modulation of Reactive Oxygen Species in Cancer Treatment
(Bentham Science, 2015-01-01)Aerobic metabolism of mammalian cells leads to the generation of reactive oxygen species (ROS). To cope with this toxicity, evolution provided cells with effective antioxidant systems like glutathione. Current anticancer ... -
Els polimorfimes del citocrom P450 i la seva repercusió en la dosificació dels medicaments
(Col·legi Oficial de Metges de Lleida, 2008) -
La farmacologia de la coagulació plasmàtica per via oral al segle XXI
(Col·legi Oficial de Metges de Lleida, 2012) -
L'aplicació d'anticossos monoclonals en terapèutica humana
(Col·legi Oficial de Metges de Lleida, 2009) -
L'aplicació d'anticossos monoclonals en terapèutica humana: Farmacologia general i indicacions concretes
(Col·legi Oficial de Metges de Lleida, 2009) -
2-phenylethynesulfonamide (PES) uncovers a necrotic process regulated by oxidative stress and p53
(Elsevier, 2014)2-Phenylethynesulfonamide (PES) or pifithrin-μ is a promising anticancer agent with preferential toxicity for cancer cells. The type of cell death and the molecular cascades activated by this compound are controversial. ... -
Cell death induced by 2-phenylethynesulfonamide uncovers a pro-survival function of BAX
(Elsevier, 2014)PES (2-phenylethynesulfonamide) was initially identified as an inhibitor of p53 translocation to mitochondria and named Pifithrin-µ. Further studies showed that PES selectively killed tumour cells and was thus a promising ... -
Accumulation of misfolded SOD1 in dorsal root ganglion degenerating propioceptive sensory neurons of transgenic mice with amyotrophic lateral sclerosis
(Hindawi Publishing Corporation, 2014)Amyotrophic lateral sclerosis (ALS) is an adult-onset progressive neurodegenerative disease affecting upper and lower motoneurons (MNs). Although the motor phenotype is a hallmark for ALS, there is increasing evidence that ... -
Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts
(American Society for Clinical Investigation, 2011)Dose-escalated radiation therapy for localized prostate cancer (PCa) has a clear therapeutic benefit; however, escalated doses may also increase injury to noncancerous tissues. Radiosensitizing agents can improve ... -
Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: possible role in Down syndrome
(Public Library of Science, 2013)Individuals with Down syndrome (DS) present important motor deficits that derive from altered motor development of infants and young children. DYRK1A, a candidate gene for DS abnormalities has been implicated in motor ... -
A novel source for miR-21 expression through the alternative polyadenylation of VMP1 gene transcripts
(Oxford University Press, 2012)miR-21 is the most commonly over-expressed microRNA (miRNA) in cancer and a proven oncogene. Hsa-miR-21 is located on chromosome 17q23.2, immediately downstream of the vacuole membrane protein-1 (VMP1) gene, also known as ...