L'IRBLleida és un centre de recerca conjunt entre la Universitat i el Departament de Salut de la Generalitat de Catalunya. Té com a funció potenciar les sinergies de recerca biomèdica entre ambdós institucions i està compromès en avançar en la recerca biomèdica com a mitja per millorar la salut de la població i facilitar una activitat assistencial òptima en situacions de malaltia. [Més informació].

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  • DPP9 as a Potential Novel Mediator in Gastrointestinal Virus Infection 

    Castillo Izquierdo, Ángela del; Moreno Navarrete, José María; Latorre, Jèssica; Arnoriaga Rodríguez, María; Ballanti, Marta; Monteleone, Giovanni; Paoluzi, Alessandro Omero; Mingrone, Geltrude; Puig, Josep; Ramos, Rafael; Garre Olmo, Josep; Jové Font, Mariona; Pamplona Gras, Reinald; Portero Otín, Manuel; Sol, Joaquim; Lefevre, Philippe; Staels, Bart; Federici, Massimo; Fernández Real, José Manuel; Mayneris Perxachs, Jordi (MDPI, 2022)
    Dipeptidyl peptidase 9 (DPP9) is a member of the dipeptidyl peptidase IV family. Inhibition of DPP9 has recently been shown to activate the nucleotide-binding domain leucine-rich repeat 1 (NLRP1) inflammasome. NLRP1 is ...
  • Traumatic Brain Injury and Acute Kidney Injury—Outcomes and Associated Risk Factors 

    Barea-Mendoza, Jesús Abelardo; Chico-Fernández, Mario; Quintana-Díaz, Manuel; Servià Goixart, Lluís; Fernández-Cuervo, Ana; Bringas-Bollada, María; Ballesteros Sanz, María Ángeles; García-Sáez, Íker; Pérez-Bárcena, Jon; Llompart-Pou, Juan Antonio (MDPI, 2022)
    Our objective was to analyze the contribution of acute kidney injury (AKI) to the mortality of isolated TBI patients and its associated risk factors. Observational, prospective and multicenter registry (RETRAUCI) methods ...
  • Are Transcription Factors Plausible Oncotargets for Triple Negative Breast Cancers? 

    Marqués, Marta; Urdanibia, Izaskun; Parisi Capdevila, Eva; Hidalgo, Iván; Morales Murillo, Serafín; Salud Salvia, Maria Antonieta; Sorolla Bardají, Anabel; Sorolla Bardají, Maria Alba (MDPI, 2022)
    Breast cancer (BC) is the most diagnosed cancer worldwide and one of the main causes of cancer deaths. BC is a heterogeneous disease composed of different BC intrinsic subtypes such as triple-negative BC (TNBC), which ...
  • Dark Triad Traits, Social Position, and Personality: A Cross-Cultural Study 

    Aluja Fabregat, Antón; García, Luis Francisco; Rossier, Jérôme; Ostendorf, Fritz; Glicksohn, Joseph; Oumar, Barry; Bellaj, Tarek; Ruch, Willibald; Wang, Wei; Suranyi, Zsuzsanna; Ścigała, Dawid; Čekrlija, Đorđe; Stivers, Adam; Di Blas, Lisa; Valdivia, Mauricio; Ben Jemaa, Sonia; Atitsogbe, Kokou A.; Hansenne, Michel (SAGE Publications, 2022)
    This research explores the Dark Triad traits in 18 cultures from Europe, America, Africa, and Asia. We examined the relationships among Dark Triad traits, as measured by the SD3, with gender, age, social status, and two ...
  • Who’s in the House? Staffing in Long-Term Care Homes Before and During COVID-19 Pandemic 

    Vellani, Shirin; Spilsbury, Karen; Zúñiga, Franziska; Backman, Annica; Kusmaul, Nancy; Scales, Kezia; Chu, Charlene H.; Mateos, José Tomás; Wang, Jing; Fagertun, Anette; McGilton, Katherine S. (SAGE Publications, 2022)
    Critical gaps exist in our knowledge on how best to provide quality person-centered care to long-term care (LTC) home residents which is closely tied to not knowing what the ideal staff is complement in the home. A ...
  • A detailed review on the phytochemical profiles and anti-diabetic mechanisms of Momordica charantia 

    Faith Oyelere, Sunday; Hezekiah Ajayi, Oluwatobi; Eunice Ayoade, Titilayo; Santana Pereira, George; Dayo Owoyemi, Bolaji Charles; Olaoluwa Ilesanmi, Ajibola; Amos Akinyemi, Olalekan (Elsevier, 2022)
    Diabetes mellitus is the most well-known endocrine dilemma suffered by hundreds of million people globally, with an annual mortality of more than one million people. This high mortality rate highlights the need for in-depth ...
  • Beyond the Glycaemic Control of Dapagliflozin: Microangiopathy and Non-classical Complications 

    Bellido, Virginia; Martínez, Julia; Calvo, Fernando; Villarroel, Aida; Lecumberri, Edurne; Moreno, Juan; Morillas, Carlos; Rodrigo, Silvia; Izarra, Aitziber; Lecube Torelló, Albert (Springer Nature, 2022)
    Dapagliflozin is a selective sodium-glucose cotransporter 2 inhibitor (SGLT2i) indicated for the treatment of type 2 diabetes mellitus (T2DM), heart failure (HF) with reduced ejection fraction (EF) and chronic kidney disease ...
  • Increase of burnout among emergency department professionals due to emotional exhaustion during the SARS-Cov2 pandemic: Evolution from 2016 to 2021 

    Yuguero Torres, Oriol; Rius, Nuria; Soler González, Jorge; Esquerda i Aresté, Montse (Wolters Kluwer Health, 2022)
    The objective is to establish there have been any significant changes in the evolution of levels of burnout and empathy at the different Emergency Department in our region, bearing the severe acute respiratory syndrome ...
  • Adjusting RFR by Predictors of Disagreement, “The Adjusted RFR”: An Alternative Methodology to Improve the Diagnostic Capacity of Coronary Indices 

    Fernández Rodríguez, Diego; Casanova Sandoval, Juan Manuel; Barriuso, Ignacio; Rivera, Kristian; Otaegui, Imanol; García del Blanco, Bruno; Gil Jiménez, Teresa; López Pérez, Manuel; Rodríguez Esteban, Marcos; Torres Saura, Francisco; Jiménez Díaz, Víctor; Ocaranza Sánchez, Raymundo; Peral Disdier, Vicente; Sánchez Elvira, Guillermo; Worner, Fernando (Sociedade Brasileira de Cardiologia, 2022)
    Background: Cutoff thresholds for the "resting full-cycle ratio" (RFR) oscillate in different series, suggesting that population characteristics may influence them. Likewise, predictors of discordance between the RFR and ...
  • Litotricia intracoronaria como rescate de un stent infraexpandido 

    Rivera, Kristian; Fernández Rodríguez, Diego; Zielonka, Marta; Barriuso, Ignacio; Pueyo, Núria; Casanova Sandoval, Juan Manuel (Permanyer, 2022)
  • Elimination of Vitamin D Signaling Causes Increased Mortality in a Model of Overactivation of the Insulin Receptor: Role of Lipid Metabolism 

    Crespo Masip, Maria; Pérez-Gómez, Aurora; Garcia Carrasco, Alicia; Jover, Ramiro; Guzmán, Carla; Dolcet Roca, Xavier; Ibarz Escuer, Mercedes; Martínez, Cristina; Eritja, Àuria; Díaz Tocados, Juan Miguel; Valdivielso Revilla, José Manuel (MDPI, 2022)
    Vitamin D (VD) deficiency has been associated with cancer and diabetes. Insulin signaling through the insulin receptor (IR) stimulates cellular responses by activating the PI3K/AKT pathway. PTEN is a tumor suppressor and ...
  • Cardiac tamponade as the initial presentation of a T-cell lymphoblastic lymphoma 

    Belokopytova-Chakh, Alena; Ruiz González, Agustín; Vilardell, Felip; Porcel Pérez, José Manuel (Sociedad Gallega de Medicina Interna, 2022)
    We report a 27-year-old man who presented with cardiac tamponade and was eventually diagnosed of T-cell lymphoblastic lymphoma (T-LBL) by the flow cytometric analysis of pericardial fluid. Despite pericardiocentesis and ...
  • Industrial By-Products As a Novel Circular Source of Biocompatible Extracellular Vesicles 

    Lorca, Cristina; Laparra, Moisés; Céspedes, María Virtudes; Casaní, Laura; Florit, Sergi; Jové Font, Mariona; Mota Martorell, Natàlia; Vilella, Elisabet; Gallart-Palau, Xavier; Serra, Aida (Wiley, 2022)
    Extracellular vesicles (EVs) constitute an intricate system of molecular exchange that has recently gained tremendous interest. However, sustainable sources of safe biological EVs remain scarce and elusive. This study ...
  • Prognostic implications of comorbidity patterns in critically ill COVID-19 patients: A multicenter, observational study 

    Benítez, Iván; Batlle Garcia, Jordi de; Torres, Gerard; González, Jessica; de Gonzalo Calvo, David; Targa, Adriano; Gort Paniello, Clara; Moncusí Moix, Anna; Ceccato, Adrián; Fernández Barat, Laia; Ferrer, Ricard; Garcia-Gasulla, Dario; Menéndez, Rosario; Motos, Anna; Peñuelas, Oscar; Riera, Jordi; Bermejo Martin, Jesús F.; Peñasco, Yhivian; Ricart, Pilar; Martin Delgado, María Cruz; Aguilera, Luciano; Rodríguez, Alejandro; Boado Varela, Maria Victoria; Suarez-Sipmann, Fernando; Pozo Laderas, Juan Carlos; Solé Violan, Jordi; Nieto, Maite; Novo, Mariana Andrea; Barberán, José; Amaya Villar, Rosario; Garnacho Montero, José; García Garmendia, José Luis; Gómez, José Manuel; Lorente, José Ángel; Blandino Ortiz, Aaron; Tamayo Lomas, Luis; López Ramos, Esther; Úbeda, Alejandro; Catalán González, Mercedes; Sánchez Miralles, Angel; Martínez Varela, Ignacio; Jorge García, Ruth Noemí; Franco, Nieves; Gumucio Sanguino, Víctor D.; Huerta, Arturo; Bustamante Munguira, Elena; Valdivia, Luis Jorge; Caballero, Jesús; Gallego, Elena; Martínez de la Gándara, Amalia; Castellanos-Ortega, Álvaro; Trenado, José; Marin Corral, Judith; Albaiceta, Guillermo M.; de la Torre, Maria del Carmen; Loza Vázquez, Ana; Vidal, Pablo; López Messa, Juan; Añón, José M.; Carbajales, Cristina; Sagredo, Victor; Bofill, Neus; Carbonell, Nieves; Socias, Lorenzo; Barberà, Carme; Estella, Ángel; Valledor Mendez, Manuel; Diaz, Emili; López Lago, Ana; Torres, Antoni; Barbé Illa, Ferran (Elsevier, 2022)
    Background: The clinical heterogeneity of COVID-19 suggests the existence of different phenotypes with prognostic implications. We aimed to analyze comorbidity patterns in critically ill COVID-19 patients and assess their ...
  • Effectiveness of medical nutrition therapy in adolescents with type 1 diabetes: a systematic review 

    Granado-Casas, Minerva; Solà, Ivan; Hernández García, Marta; Rojo López, Marina Idalia; Julve, Josep; Mauricio Puente, Dídac (Springer Nature, 2022)
    BACKGROUND: Medical nutrition therapy (MNT) has an integral role in overall diabetes management. During adolescence, consideration of physiological and psychosocial changes is essential for implementing an optimal diabetes ...
  • Seroprevalence of SARS-CoV-2 in a Cohort of Patients with Multiple Sclerosis under Disease-Modifying Therapies 

    Sancho Saldaña, Agustín; Gil Sánchez, Anna; Quirant Sánchez, Bibiana; Nogueras Penabad, Lara; Peralta Moncusí, Silvia; Solana Moga, M. José; González Mingot, Cristina; Gallego, Yhovanni; Quibus, Laura; Ramo Tello, Cristina; Presas Rodríguez, Silvia; Martínez Cáceres, Eva; Torres Cabestany, Pascual; Hervás, J.V.; Valls, Joan; Brieva Ruiz, Luis (MDPI, 2022)
    Background: Disease-modifying therapies (DMTs) used to treat multiple sclerosis (MS) alter the immune system and therefore increase the risk of infection. There is growing concern about the impact of COVID-19 on patients ...
  • Influence of Malignant Pleural Fluid from Lung Adenocarcinoma Patients on Neutrophil Response 

    Mulet, Maria; Osuna Gómez, Rubén; Zamora, Carlos; Porcel Pérez, José Manuel; Nieto, Juan C.; Perea, Lídia; Pajares, Virginia; Muñoz-Fernandez, Ana M.; Calvo, Nuria; Sorolla Bardají, Maria Alba; Vidal, Silvia (MDPI, 2022)
    Malignant pleural effusion (MPE) is a common severe complication of advanced lung adenocarcinoma (LAC). Neutrophils, an essential component of tumor infiltrates, contribute to tumor progression and their counts in MPE ...
  • NaroNet: Discovery of tumor microenvironment elements from highly multiplexed images 

    Jiménez Sánchez, Daniel; Ariz, Mikel; Chang, Hang; Matias-Guiu, Xavier; De Andrea, Carlos; Ortiz-De-Solórzano, Carlos (Elsevier, 2022)
    Understanding the spatial interactions between the elements of the tumor microenvironment -i.e. tumor cells. fibroblasts, immune cells- and how these interactions relate to the diagnosis or prognosis of a tu mor is one ...
  • Epidemiological and clinical characteristics of SARS-CoV-2 reinfections in a Spanish region 

    Yuguero Torres, Oriol; Companys, Maria; Guzmán, Marianela; Maciel, Rita; Llobet, Cecilia; López, Aurora; Olles, Rebeca; Pujol, Violant; Ruiz Montilla, María José; Saura, Mireia; Vidal, Carme; Godoy i García, Pere (SAGE Publications, 2022)
    Objective: We aimed to assess the prevalence and clinical characteristics of SARS-CoV-2 reinfections in a Spanish region. Methods: This is a retrospective observational study in all patients with SARS-CoV-2 infections in ...
  • Metabolomic Analysis Points to Bioactive Lipid Species and Acireductone Dioxygenase 1 (ADI1) as Potential Therapeutic Targets in Poor Prognosis Endometrial Cancer 

    Gatius Calderó, Sònia; Jové Font, Mariona; Megino-Luque, Cristina; Albertí Valls, Manel; Yeramian Hakim, Andree; Bonifaci, Núria; Piñol, Miquel; Santacana Espasa, Maria; Pradas Barriga, Irene; Llobet Navàs, David; Pamplona Gras, Reinald; Matías-Guiu, Xavier; Eritja Sánchez, Núria (MDPI, 2022)
    Metabolomic profiling analysis has the potential to highlight new molecules and cellular pathways that may serve as potential therapeutic targets for disease treatment. In this study, we used an LC-MS/MS platform to define, ...

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