Recent Submissions

  • Survival motor neuron protein and neurite degeneration are regulated by Gemin3 in spinal muscular atrophy motoneurons 

    Miralles, Maria P.; Sansa Zaragoza, Alba; Beltran Perelló, Maria; Soler i Tatché, Rosa Ma.; Garcera, Ana (Frontiers Media, 2022)
    Spinal Muscular Atrophy (SMA) is a genetic neuromuscular disorder caused by reduction of the ubiquitously expressed protein Survival Motor Neuron (SMN). Low levels of SMN impact on spinal cord motoneurons (MNs) causing ...
  • DPP9 as a Potential Novel Mediator in Gastrointestinal Virus Infection 

    Castillo Izquierdo, Ángela del; Moreno Navarrete, José María; Latorre, Jèssica; Arnoriaga Rodríguez, María; Ballanti, Marta; Monteleone, Giovanni; Paoluzi, Alessandro Omero; Mingrone, Geltrude; Puig, Josep; Ramos, Rafael; Garre Olmo, Josep; Jové Font, Mariona; Pamplona Gras, Reinald; Portero Otín, Manuel; Sol, Joaquim; Lefevre, Philippe; Staels, Bart; Federici, Massimo; Fernández Real, José Manuel; Mayneris Perxachs, Jordi (MDPI, 2022)
    Dipeptidyl peptidase 9 (DPP9) is a member of the dipeptidyl peptidase IV family. Inhibition of DPP9 has recently been shown to activate the nucleotide-binding domain leucine-rich repeat 1 (NLRP1) inflammasome. NLRP1 is ...
  • Industrial By-Products As a Novel Circular Source of Biocompatible Extracellular Vesicles 

    Lorca, Cristina; Laparra, Moisés; Céspedes, María Virtudes; Casaní, Laura; Florit, Sergi; Jové Font, Mariona; Mota Martorell, Natàlia; Vilella, Elisabet; Gallart-Palau, Xavier; Serra, Aida (Wiley, 2022)
    Extracellular vesicles (EVs) constitute an intricate system of molecular exchange that has recently gained tremendous interest. However, sustainable sources of safe biological EVs remain scarce and elusive. This study ...
  • Seroprevalence of SARS-CoV-2 in a Cohort of Patients with Multiple Sclerosis under Disease-Modifying Therapies 

    Sancho Saldaña, Agustín; Gil Sánchez, Anna; Quirant Sánchez, Bibiana; Nogueras Penabad, Lara; Peralta Moncusí, Silvia; Solana Moga, M. José; González Mingot, Cristina; Gallego, Yhovanni; Quibus, Laura; Ramo Tello, Cristina; Presas Rodríguez, Silvia; Martínez Cáceres, Eva; Torres Cabestany, Pascual; Hervás, J.V.; Valls, Joan; Brieva Ruiz, Luis (MDPI, 2022)
    Background: Disease-modifying therapies (DMTs) used to treat multiple sclerosis (MS) alter the immune system and therefore increase the risk of infection. There is growing concern about the impact of COVID-19 on patients ...
  • Enhancing Night and Day Circadian Contrast through Sleep Education in Prediabetes and Type 2 Diabetes Mellitus: A Randomized Controlled Trial 

    García Serrano, Cristina; Pujol Salud, Jesús; Aran Solé, Lidia; Sol, Joaquim; Ortiz Congost, Sònia; Artigues i Barberà, Eva María; Ortega Bravo, Marta (MDPI, 2022)
    Background: Evidence supports a causal relationship between circadian disturbance and impaired glucose homeostasis. Methods: To determine the effect of an educational intervention delivered by primary care nurses to ...
  • Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function 

    Mayneris Perxachs, Jordi; Arnoriaga Rodríguez, María; Garre Olmo, Josep; Puig, Josep; Ramos, Rafael; Trelis, Maria; Burokas, Aurelijus; Coll, Clàudia; Zapata, Cristina; Pedraza, Salvador; Pérez Brocal, Vicente; Ramió Torrentà, Lluís; Ricart, Wifredo; Moya, Andrés; Jové Font, Mariona; Sol, Joaquim; Portero Otín, Manuel; Pamplona Gras, Reinald; Maldonado, Rafael; Fernández Real, José Manuel (Springer Nature, 2022)
    Growing evidence implicates the gut microbiome in cognition. Blastocystis is a common gut single-cell eukaryote parasite frequently detected in humans but its potential involvement in human pathophysiology has been poorly ...
  • Genistein effect on cognition in prodromal Alzheimer's disease patients. The GENIAL clinical trial 

    José, Viña; Escudero, Joaquín; Baquero, Miquel; Cebrián, Mónica; Carbonell Asíns, Juan Antonio; Muñoz, José Enrique; Satorres, Encarnación; Meléndez, Juan Carlos; Ferrer Rebolleda, José; Cózar Santiago, Mª Del Puig; Santabárbara Gómez, Jose Manuel; Jové Font, Mariona; Pamplona Gras, Reinald; Tarazona Santabalbina, Francisco José; Borrás, Consuelo (BMC, 2022)
    Background: Delaying the transition from minimal cognitive impairment to Alzheimer’s dementia is a major concern in Alzheimer’s disease (AD) therapeutics. Pathological signs of AD occur years before the onset of clinical ...
  • Blood-based lipidomic signature of severe obstructive sleep apnoea in Alzheimer's disease 

    Dakterzada, Farida; Benítez, Iván; Targa, Adriano; Carnes, Anna; Pujol, Montserrat; Minguez Roure, Olga; Vaca, Rafaela; Sánchez de la Torre, Manuel; Barbé Illa, Ferran; Pamplona Gras, Reinald; Piñol Ripoll, Gerard (BCM, 2022)
    Background: Obstructive sleep apnoea (OSA) is the most frequent form of sleep-disordered breathing in patients with Alzheimer’s disease (AD). Available evidence demonstrates that both conditions are independently associated ...
  • A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers 

    Torres Cabestany, Pascual; Anerillas Aljama, Carlos; Ramírez Núñez, Omar; Encinas Martín, Mario; Povedano, Mònica; Andrés-Benito, Pol; Ferrer, Isidre; Ayala Jové, Ma. Victoria (Maria Victoria); Pamplona Gras, Reinald; Portero Otín, Manuel (The Company of Biologists, 2022)
    To evaluate senescence mechanisms, including senescence associated secretory phenotype (SASP), in the motor neuron disease model hSOD1-G93A, we quantified the expression of p16 and p21 and senescence-associated β-galactosidase ...
  • mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity 

    Mota Martorell, Natàlia; Jové Font, Mariona; Pamplona Gras, Reinald (MDPI, 2022)
    Decreased content and activity of the mechanistic target of rapamycin (mTOR) signalling pathway, as well as the mTOR complex 1 (mTORC1) itself, are key traits for animal species and human longevity. Since mTORC1 acts as ...
  • Differences in Free-Living Patterns of Sedentary Behaviour between Office Employees with Diabetes and Office Employees without Diabetes: A Principal Component Analysis for Clinical Practice 

    Alòs, Francesc; Colomer, M. Àngels (Maria Àngels); Bort Roig, Judit; Chirveches Pérez, Emilia; Cánovas Zaldúa, Yoseba; Martín Cantera, Carlos; Franch-Nadal, Josep; Puig Ribera, Anna (MDPI, 2022)
    Aims: To identify principal components of free-living patterns of sedentary behaviour in office employees with type 2 diabetes (T2D) compared to normal glucose metabolism (NGM) office employees, using principal component ...
  • ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma 

    Concin, Nicole; Matias-Guiu, Xavier; Vergote, Ignace; Cibula, David; Raza Mirza, Mansoor; Marnitz, Simone; Ledermann, Jonathan; Bosse, Tjalling; Chargari, Cyrus; Fagotti, Anna; Fotopoulou, Christina; Gonzalez Martin, Antonio; Lax, Sigurd; Lorusso, Domenica; Marth, Christian; Morice, Philippe; Nout, Remi; O'Donnell, Dearbhaile; Querleu, Denis; Raspollini, Maria Rosaria; Sehouli, Jalid; Sturdza, Alina; Taylor, Alexandra; Westermann, Anneke; Wimberger, Pauline; Colombo, Nicoletta; Planchamp, François; Creutzberg, Carien (BMJ, 2021)
    A European consensus conference on endometrial carcinoma was held in 2014 to produce multi-disciplinary evidence-based guidelines on selected questions. Given the large body of literature on the management of endometrial ...
  • Dietary AGEs as Exogenous Boosters of Inflammation 

    Garay Sevilla, Ma. Eugenia; Rojas, Armando; Portero Otín, Manuel; Uribarri, Jaime (MDPI, 2021)
    Most chronic modern non-transmissible diseases seem to begin as the result of low-grade inflammation extending over prolonged periods of time. The importance of diet as a source of many pro-inflammatory compounds that could ...
  • Corrigendum: Genetic Identification of the Central Nucleus and Other Components of the Central Extended Amygdala in Chicken During Development 

    Vicario Andrade, Alba; Abellán Ródenas, Antonio; Desfilis, Ester; Medina Hernández, Loreta Mª (Frontiers Media, 2021)
  • A dominant negative mutation uncovers cooperative control of caudal Wolffian duct development by Sprouty genes 

    Altés, Gisela; Vaquero, Marta; Cuesta, Sara; Anerillas Aljama, Carlos; Macià Armengol, Anna; Espinet Mestre, Carme; Ribera i Calvet, Joan; Bellusci, Saverio; Klein, Ophir D.; Yeramian Hakim, Andree; Dolcet Roca, Xavier; Egea Navarro, Joaquim; Encinas Martín, Mario (Springer, 2022)
    The Wolffian ducts (WD) are paired epithelial tubules central to the development of the mammalian genitourinary tract. Outgrowths from the WD known as the ureteric buds (UB) generate the collecting ducts of the kidney. ...
  • Selective brain regional changes in lipid profile with human aging 

    Mota Martorell, Natàlia; Andrés Benito, Pol; Martín Garí, Meritxell; Galo-Licona, José Daniel; Sol, Joaquim; Fernández Bernal, Anna; Portero Otín, Manuel; Ferrer, Isidre; Jové Font, Mariona; Pamplona Gras, Reinald (Springer, 2022)
    Fatty acids are key components in the structural diversity of lipids and play a strategic role in the functional properties of lipids which determine the integrity of neuronal and glial cell membranes, the generation of ...
  • Beneficial effects of dietary supplementation with green tea catechins and cocoa flavanols on aging-related regressive changes in the mouse neuromuscular system 

    Gras Artells, Sílvia; Blasco Carmona, Alba; Mòdol-Caballero, Guillem; Tarabal Mostazo, Olga; Casanovas i Llorens, Anna; Piedrafita Llorens, Lídia; Barranco, Alejandro; Das, Tapas; Rueda, Ricardo; Pereira, Suzette L.; Navarro, Xavier; Esquerda Colell, Josep; Calderó i Pardo, Jordi (Impact Journals, 2021)
    Besides skeletal muscle wasting, sarcopenia entails morphological and molecular changes in distinct components of the neuromuscular system, including spinal cord motoneurons (MNs) and neuromuscular junctions (NMJs); moreover, ...
  • SMN is physiologically down-regulated at wild-type motor nerve terminals but aggregates together with neurofilaments in SMA mouse models 

    Franco Espin, Julio; Gatius, Alaó; Armengol, José Ángel; Arumugam, Saravanan; Moradi, Mehdi; Sendtner, Michael; Calderó i Pardo, Jordi; Tabares, Lucía (MDPI, 2022)
    Survival motor neuron (SMN) is an essential and ubiquitously expressed protein that participates in several aspects of RNA metabolism. SMN deficiency causes a devastating motor neuron disease called spinal muscular atrophy ...
  • Lack of extracellular matrix switches TGF-β induced apoptosis of endometrial cells to epithelial to mesenchymal transition 

    Ruiz Mitjana, Anna; Navaridas Fernández de Bobadilla, Raúl; Vidal Sabanés, Maria; Perramon Güell, Aida; Yeramian Hakim, Andree; Felip Nogués, Isidre; Eritja Sánchez, Núria; Egea Navarro, Joaquim; Encinas Martín, Mario; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Nature Research, 2022)
    The extracellular matrix and the correct establishment of epithelial cell polarity plays a critical role in epithelial cell homeostasis and cell polarity. In addition, loss of tissue structure is a hallmark of carcinogenesis. ...
  • Development and Validation of a Personalized, Sex-Specific Prediction Algorithm of Severe Atheromatosis in Middle-Aged Asymptomatic Individuals: The ILERVAS Study 

    Bermúdez López, Marcelino; Martí Antonio, Manuel; Castro-Boqué, Eva; Bretones, María Del Mar; Farràs-Sallés, Cristina; Torres, Gerard; Pamplona Gras, Reinald; Lecube Torelló, Albert; Mauricio Puente, Dídac; Valdivielso Revilla, José Manuel; Fernández i Giráldez, Elvira (Frontiers Media, 2022)
    Background: Although European guidelines recommend vascular ultrasound for the assessment of cardiovascular risk in low-to-moderate risk individuals, no algorithm properly identifies patients who could benefit from it. The ...

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