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  • Impact of a Primary Care Antimicrobial Stewardship Program on Bacterial Resistance Control and Ecological Imprint in Urinary Tract Infections 

    Jover, Alfredo; Ramírez-Hidalgo, María; Bellés Bellés, Alba; Ribes Murillo, Esther; Batlle Bosch, Meritxell; Cayado Cabanillas, José; Garrido-Calvo, Sònia; Gracia Vilas, María Isabel; Gros Navés, Laura; Javierre Caudevilla, María Jesús; Mari López, Alba; Montull Navarro, Lidia; Ortiz Valls, Mireia; Terrer Manrique, Gemma; Vaqué Castilla, Pilar; Ichart Tomás, José Javier; Justribó Sánchez, Elena; Andreu Mayor, Ester; Carrera Guiu, Joan; Martorell Solé, Roser; Pallàs Satué, Silvia; Saura Codina, Mireia; Vena Martínez, Ana; Albalat Samper, José Manuel; Cano Marrón, Susana; Chacón Domínguez, Isabel; de la Rica Escuin, David; Estadella Servalls, María José; Figueres Farreny, Ana M.; Minguet Vidal, Sonia; Montaña Esteban, Luís Miguel; Otal Bareche, Josep; Pallerola Planes, Mercè; Pujol Aymerich, Francesc; Rodríguez Garrocho, Andrés; Solé Curcó, Antoni; Toribio Redondo, Francisca; Urgelés Castillón, María Cruz; Valgañon Palacios, Juan; Torres Puig-gros, Joan (MDPI, 2022)
    Antimicrobial stewardship programs (ASPs) are a central component in reducing the overprescription of unnecessary antibiotics, with multiple studies showing benefits in the reduction of bacterial resistance. Less commonly, ...
  • Proteomic profiling for prediction of recurrent cardiovascular event in patients with acute coronary syndrome and obstructive sleep apnea: A post-hoc analysis from the ISAACC study 

    Zapater, Andrea; Gracia-Lavedan, Esther; Torres, Gerard; Minguez Roure, Olga; Pascual, Lydia; Cortijo, Anunciación; Martínez, Dolores; Benítez, Iván; Batlle Garcia, Jordi de; Henríquez Beltrán, Mario; Abad, Jorge; Durán-Cantolla, Joaquín; Urrutia, Amaia; Mediano, Olga; Masdeu, María José; Ordax-Carbajo, Estrella; Masa, Juan Fernando; Peña, Mónica de la; Mayós Pérez, Mercè; Coloma, Ramón; Montserrat, Josep Maria; Chiner, Eusebi; Barbé Illa, Ferran; Sánchez de la Torre, Manuel (Elsevier, 2023)
    Background: Obstructive sleep apnea (OSA) is associated with a recurrent cardiovascular event (CVE) risk in patients with a first acute coronary syndrome (ACS). However, the pathological pathways by which OSA promotes this ...
  • Traumatic Brain Injury and Acute Kidney Injury—Outcomes and Associated Risk Factors 

    Barea-Mendoza, Jesús Abelardo; Chico-Fernández, Mario; Quintana-Díaz, Manuel; Servià Goixart, Lluís; Fernández-Cuervo, Ana; Bringas-Bollada, María; Ballesteros Sanz, María Ángeles; García-Sáez, Íker; Pérez-Bárcena, Jon; Llompart-Pou, Juan Antonio (MDPI, 2022)
    Our objective was to analyze the contribution of acute kidney injury (AKI) to the mortality of isolated TBI patients and its associated risk factors. Observational, prospective and multicenter registry (RETRAUCI) methods ...
  • Adherence to treatment for hypothyroidism in pregnancy and relationship with thyrotropin control: a retrospective observational cohort study 

    Siscart, Júlia; Orós, Míriam; Serna Arnaiz, Catalina; Perejón, Dani; Galván, Leonardo; Ortega Bravo, Marta (BMC, 2022)
    Background Hypothyroidism is the second most common endocrinological disease during pregnancy, with percentages that can range between 3.2 and 5.5%. A good maternal and foetal health outcome depends on thyroid hormone ...
  • Are Transcription Factors Plausible Oncotargets for Triple Negative Breast Cancers? 

    Marqués, Marta; Urdanibia, Izaskun; Parisi Capdevila, Eva; Hidalgo, Iván; Morales Murillo, Serafín; Salud Salvia, Maria Antonieta; Sorolla Bardají, Anabel; Sorolla Bardají, Maria Alba (MDPI, 2022)
    Breast cancer (BC) is the most diagnosed cancer worldwide and one of the main causes of cancer deaths. BC is a heterogeneous disease composed of different BC intrinsic subtypes such as triple-negative BC (TNBC), which ...
  • Beyond the Glycaemic Control of Dapagliflozin: Microangiopathy and Non-classical Complications 

    Bellido, Virginia; Martínez, Julia; Calvo, Fernando; Villarroel, Aida; Lecumberri, Edurne; Moreno, Juan; Morillas, Carlos; Rodrigo, Silvia; Izarra, Aitziber; Lecube Torelló, Albert (Springer Nature, 2022)
    Dapagliflozin is a selective sodium-glucose cotransporter 2 inhibitor (SGLT2i) indicated for the treatment of type 2 diabetes mellitus (T2DM), heart failure (HF) with reduced ejection fraction (EF) and chronic kidney disease ...
  • Increase of burnout among emergency department professionals due to emotional exhaustion during the SARS-Cov2 pandemic: Evolution from 2016 to 2021 

    Yuguero Torres, Oriol; Rius, Nuria; Soler González, Jorge; Esquerda i Aresté, Montse (Wolters Kluwer Health, 2022)
    The objective is to establish there have been any significant changes in the evolution of levels of burnout and empathy at the different Emergency Department in our region, bearing the severe acute respiratory syndrome ...
  • LRP1 loss in airway epithelium exacerbates smoke-induced oxidative damage and airway remodeling 

    Garcia-Arcos, Itsaso; Park, Sangmi S.; Mai, Michelle; Alvarez-Buvé, Roger; Chow, Lilian; Cai, Huchong; Baumlin-Schmid, Nathalie; Agudelo, Christina; Kim, Michael; Salathe, Matthias; Goldberg, Ira J.; Foronjy, Robert; Dabo, Abdoulaye (Elsevier, 2022)
    The LDL receptor-related protein 1 (LRP1) partakes in metabolic and signaling events regulated in a tissue-specific manner. The function of LRP1 in airways has not been studied. We aimed to study the function of LRP1 in ...
  • Elimination of Vitamin D Signaling Causes Increased Mortality in a Model of Overactivation of the Insulin Receptor: Role of Lipid Metabolism 

    Crespo Masip, Maria; Pérez-Gómez, Aurora; Garcia Carrasco, Alicia; Jover, Ramiro; Guzmán, Carla; Dolcet Roca, Xavier; Ibarz Escuer, Mercedes; Martínez, Cristina; Eritja, Àuria; Díaz Tocados, Juan Miguel; Valdivielso Revilla, José Manuel (MDPI, 2022)
    Vitamin D (VD) deficiency has been associated with cancer and diabetes. Insulin signaling through the insulin receptor (IR) stimulates cellular responses by activating the PI3K/AKT pathway. PTEN is a tumor suppressor and ...
  • Cardiac tamponade as the initial presentation of a T-cell lymphoblastic lymphoma 

    Belokopytova-Chakh, Alena; Ruiz González, Agustín; Vilardell, Felip; Porcel Pérez, José Manuel (Sociedad Gallega de Medicina Interna, 2022)
    We report a 27-year-old man who presented with cardiac tamponade and was eventually diagnosed of T-cell lymphoblastic lymphoma (T-LBL) by the flow cytometric analysis of pericardial fluid. Despite pericardiocentesis and ...
  • Effectiveness of medical nutrition therapy in adolescents with type 1 diabetes: a systematic review 

    Granado-Casas, Minerva; Solà, Ivan; Hernández García, Marta; Rojo López, Marina Idalia; Julve, Josep; Mauricio Puente, Dídac (Springer Nature, 2022)
    BACKGROUND: Medical nutrition therapy (MNT) has an integral role in overall diabetes management. During adolescence, consideration of physiological and psychosocial changes is essential for implementing an optimal diabetes ...
  • Seroprevalence of SARS-CoV-2 in a Cohort of Patients with Multiple Sclerosis under Disease-Modifying Therapies 

    Sancho Saldaña, Agustín; Gil Sánchez, Anna; Quirant Sánchez, Bibiana; Nogueras Penabad, Lara; Peralta Moncusí, Silvia; Solana Moga, M. José; González Mingot, Cristina; Gallego, Yhovanni; Quibus, Laura; Ramo Tello, Cristina; Presas Rodríguez, Silvia; Martínez Cáceres, Eva; Torres Cabestany, Pascual; Hervás, J.V.; Valls, Joan; Brieva Ruiz, Luis (MDPI, 2022)
    Background: Disease-modifying therapies (DMTs) used to treat multiple sclerosis (MS) alter the immune system and therefore increase the risk of infection. There is growing concern about the impact of COVID-19 on patients ...
  • Influence of Malignant Pleural Fluid from Lung Adenocarcinoma Patients on Neutrophil Response 

    Mulet, Maria; Osuna Gómez, Rubén; Zamora, Carlos; Porcel Pérez, José Manuel; Nieto, Juan C.; Perea, Lídia; Pajares, Virginia; Muñoz-Fernandez, Ana M.; Calvo, Nuria; Sorolla Bardají, Maria Alba; Vidal, Silvia (MDPI, 2022)
    Malignant pleural effusion (MPE) is a common severe complication of advanced lung adenocarcinoma (LAC). Neutrophils, an essential component of tumor infiltrates, contribute to tumor progression and their counts in MPE ...
  • NaroNet: Discovery of tumor microenvironment elements from highly multiplexed images 

    Jiménez Sánchez, Daniel; Ariz, Mikel; Chang, Hang; Matias-Guiu, Xavier; De Andrea, Carlos; Ortiz-De-Solórzano, Carlos (Elsevier, 2022)
    Understanding the spatial interactions between the elements of the tumor microenvironment -i.e. tumor cells. fibroblasts, immune cells- and how these interactions relate to the diagnosis or prognosis of a tu mor is one ...
  • Epidemiological and clinical characteristics of SARS-CoV-2 reinfections in a Spanish region 

    Yuguero Torres, Oriol; Companys, Maria; Guzmán, Marianela; Maciel, Rita; Llobet, Cecilia; López, Aurora; Olles, Rebeca; Pujol, Violant; Ruiz Montilla, María José; Saura, Mireia; Vidal, Carme; Godoy i García, Pere (SAGE Publications, 2022)
    Objective: We aimed to assess the prevalence and clinical characteristics of SARS-CoV-2 reinfections in a Spanish region. Methods: This is a retrospective observational study in all patients with SARS-CoV-2 infections in ...
  • Metabolomic Analysis Points to Bioactive Lipid Species and Acireductone Dioxygenase 1 (ADI1) as Potential Therapeutic Targets in Poor Prognosis Endometrial Cancer 

    Gatius Calderó, Sònia; Jové Font, Mariona; Megino-Luque, Cristina; Albertí Valls, Manel; Yeramian Hakim, Andree; Bonifaci, Núria; Piñol, Miquel; Santacana Espasa, Maria; Pradas Barriga, Irene; Llobet Navàs, David; Pamplona Gras, Reinald; Matías-Guiu, Xavier; Eritja Sánchez, Núria (MDPI, 2022)
    Metabolomic profiling analysis has the potential to highlight new molecules and cellular pathways that may serve as potential therapeutic targets for disease treatment. In this study, we used an LC-MS/MS platform to define, ...
  • Beyond the Glycaemic Control of Dapagliflozin: Impact on Arterial Stiffness and Macroangiopathy 

    González Clemente, José M.; García Castillo, María; Gorgojo Martínez, Juan J.; Jiménez, Alberto; Llorente, Ignacio; Matute, Eduardo; Tejera, Cristina; Izarra, Aitziber; Lecube Torelló, Albert (Springer Nature, 2022)
    Dapagliflozin is a selective sodium–glucose cotransporter 2 inhibitor (SGLT2i) indicated for the treatment of type 2 diabetes mellitus (T2DM), heart failure with reduced ejection fraction and chronic kidney disease. In all ...
  • Psychometric properties of the Spanish version of the Psychopathy Checklist: Youth Version 

    Ivanova Serokhvostova, Anastasiya; Molinuevo, Beatriz; González, Leonor; Hilterman, Ed; Pardo, Yolanda; Pera Guardiola, Vanessa; Bonillo, Albert; Batalla, Iolanda; Torrubia, Rafael; Forth, Adelle (Springer Nature, 2022)
    The current study examined the psychometric properties (factor structure, reliability and validity) of the Psychopathy Checklist: Youth Version (PCL:YV; Forth et al., 2003) in Spanish samples of male justice-involved youths ...
  • Diabetic retinopathy predicts cardiovascular disease independently of subclinical atherosclerosis in individuals with type 2 diabetes: A prospective cohort study 

    Castelblanco Echavarría, Esmeralda; Granado Casas, Minerva; Hernández García, Marta; Pinyol, Montserrat; Correig, Eudald; Julve, Josep; Rojo López, Marina Idalia; Alonso, Núria; Avogaro, Angelo; Ortega, Emilio; Mauricio Puente, Dídac (Frontiers, 2022)
    Background: Diabetic retinopathy (DR) and preclinical atherosclerosis are associated with higher cardiovascular risk. However, no studies have investigated the predictive role of DR and preclinical atherosclerosis jointly ...
  • Blood-based lipidomic signature of severe obstructive sleep apnoea in Alzheimer's disease 

    Dakterzada, Farida; Benítez, Iván; Targa, Adriano; Carnes, Anna; Pujol, Montserrat; Minguez Roure, Olga; Vaca, Rafaela; Sánchez de la Torre, Manuel; Barbé Illa, Ferran; Pamplona Gras, Reinald; Piñol Ripoll, Gerard (BCM, 2022)
    Background: Obstructive sleep apnoea (OSA) is the most frequent form of sleep-disordered breathing in patients with Alzheimer’s disease (AD). Available evidence demonstrates that both conditions are independently associated ...

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