- ItemEmbargoHigh season is coming: travel motivations of Game of Thrones fans(Taylor and Francis Group, 2023-10-27) Gómez Morales, Beatriz Maria; Castro, Deborah; Nieto Ferrando, JorgeDespite substantial evidence that media fans are increasingly travelling to the filming locations for movies and TV series, research on core tribal fan film tourists’ travel motivations remains limited. This paper contributes to the scarce literature on this question with a study of the fan tourism phenomenon inspired by the fiction TV series Game of Thrones. The study is based on 68 semi-structured in-depth interviews with fans of the series; specifically, core fan community members who have travelled to one or more of the series’ filming locations. A thematic analysis of the interview responses reveals three main travel motivations: affective identification with characters; the existence of parallels between fiction and history; and the desire to feel part of a collective identity. The findings suggest that tourism motivated by Game of Thrones is the result of a profound emotional and narrative attachment to the series on the part of fans, with a combination of playful and serious elements. On the theoretical level, this paper contributes to the scholarly literature on fan film tourism. It also reveals that a better understanding of fans’ needs could support tourist destination managers in the creation of added value for fan film tourists.
- ItemOpen AccessUn éxito de Joseph Van der Veken en España: el tríptico pseudoflamenco del conde de La Revilla(Departamento de Historia del Arte de la Universidad de Valladolid, 2023-12-01) Velasco González, Alberto; Martens, DidierEn el presente artículo se da a conocer un tríptico pseudoflamenco pintado hacia finales del siglo XIX o inicios del XX por Joseph Van der Veken (1872-1964), un restaurador, copista y falsificador de Amberes mundialmente conocido por su habilidad en la reproducción de pinturas flamencas. La realización de esta obra se inscribe en el contexto de revaloración de la pintura flamenca de los siglos XV y XVI, que generó una producción a gran escala de falsificaciones debido a la gran demanda existente en el mercado europeo. Estas obras espurias también se comercializaron en España, llegando a introducirse en colecciones importantes y pasando inadvertidas a ojos expertos. En el caso que nos ocupa, el tríptico de Van der Veken, entonces propiedad del coleccionista Francisco de Paula Arróspide Álvarez, XIII Conde de La Revilla, llegó a exhibirse como un original en la Exposición Internacional de Barcelona de 1929.
- ItemEmbargoLabour trafficking prosecution: what is not working in Spain?(Taylor and Francis Group, 2023) Villacampa Estiarte, CarolinaDespite being one of the most prevalent manifestations of trafficking in human beings, labour exploitation still results in few convictions. Based on 33 interviews with 28 professionals from the criminal justice system and 5 from the field of labour, this paper analyses the obstacles these professionals face when approaching this crime in Spain as a case study of what may not be working in other Western European countries. The research results point to three types of barriers encountered when dealing with these cases: regulatory; institutional (both pretrial and extra-procedural and during the criminal proceedings themselves); and those related to professionals’ attitudes towards these cases. The difficulties that can be included in each of these areas are identified, and solutions are proposed to overcome them to make the criminal justice system’s response to this crime more effective.
- ItemOpen AccessMetformin exhibits antineoplastic effects on Pten-deficient endometrial cancer by interfering with TGF-β and p38/ERK MAPK signalling(Elsevier, 2023) Ruiz Mitjana, Anna; Vidal Sabanés, Maria; Navaridas Fernández de Bobadilla, Raúl; Perramon Güell, Aida; Yeramian Hakim, Andree; Nicholson Sabaté, Nathan; Egea Navarro, Joaquim; Encinas Martín, Mario; Matias-Guiu, Xavier; Dolcet Roca, XavierMetformin is a widespread antidiabetic agent that is commonly used as a treatment against type 2 diabetes mellitus patients. Regarding its therapeutic potential, multiple studies have concluded that Metformin exhibits antineoplastic activity on several types of cancer, including endometrial carcinoma. Although Metformin’s antineoplastic activity is well documented, its cellular and molecular anticancer mechanisms are still a matter of controversy because a plethora of anticancer mechanisms have been proposed for different cancer cell types. In this study, we addressed the cellular and molecular mechanisms of Metformin’s antineoplastic activity by using both in vitro and in vivo studies of Pten-loss driven carcinoma mouse models. In vivo, Metformin reduced endometrial neoplasia initiated by Pten-deficiency. Our in vitro studies using Pten-deficient endometrial organoids focused on both cellular and molecular levels in Metformin’s tumor suppressive action. At cellular level, we showed that Metformin is involved in not only the proliferation of endometrial epithelial cells but also their regulation via a variety of mechanisms of epithelial-to-mesenchymal transition (EMT) as well as TGF-β-induced apoptosis. At the molecular level, Metformin was shown to affect the TGF-β signalling., a widely known signal that plays a pivotal role in endometrial carcinogenesis. In this respect, Metformin restored TGF-β-induced apoptosis of Pten-deficient endometrial organoids through a p38-dependent mechanism and inhibited TGF-β-induced EMT on no-polarized endometrial epithelial cells by inhibiting ERK/MAPK signalling. These results provide new insights into the link between the cellular and molecular mechanism for Metformin’s antineoplastic activity in Pten-deficient endometrial cancers.
- ItemEmbargoCharacterisation of the COMFORTBOARD gypsum board for thermal energy storage in buildings(Elsevier, 2024) Marín, Paula E.; Ushak, Svetlana; Gracia Cuesta, Alvaro de; Cabeza, Luisa F.Currently, the construction sector contributes considerably to the total energy consumption and greenhouse gas emissions into the atmosphere. Thermal energy storage (TES) systems are alternatives to increase the thermal inertia of buildings, aiming to use less energy, improve thermal comfort and reduce temperature fluctuations of interior spaces. One of the possible applications in buildings is to increase their thermal mass by impregnating phase change materials (PCM) in porous construction materials, e.g., gypsum boards. In this investigation, a commercial gypsum board impregnated with PCM (Knauf Comfortboard - BASF) was investigated by carrying out a structural and thermal characterisation. The thermal response obtained agrees with the product's technical data sheet provided by the supplier. The results of the thermal characterisation show that the inclusion of PCM in the gypsum board decreased the U-value by 2 % compared to the control sample (no PCM), increased the heat storage capacity by around 45 %, improved the thermal dynamic characteristics of the material by decreasing the thermal stability coefficient from 0.92 to 0.76 and increasing the thermal lag from 0.27 to 0.49 h. Our results sustain the potential application of commercial gypsum boards with PCM under environmental conditions across a wide range of daily temperature fluctuations (e.g., The North of Chile).